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Index > Protein center > Thra(Gene name) > Rat
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  • Thra (Gene name),
  • Thyroid hormone receptor alpha (Protein name ),  THA_RAT from NCBI database.
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  • General Annotation
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  • Gene name:
    Thra(C-erba-alpha;Nr1a1);
    Protein name:
    Thyroid hormone receptor alpha;
    Alternative:
    c-erbA-1;Nuclear receptor subfamily 1 group A member 1;c-erbA-alpha;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with AKAP13 and C1D.
    Function:
    Nuclear hormone receptor. High affinity receptor for triiodothyronine.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    492
    Sequence:
    50:
    MEQKPSKVEC | GSDPEENSAR | SPDGKRKRKN | GQCPLKSSMS | GYIPSYLDKD | 
    100:
    EQCVVCGDKA | TGYHYRCITC | EGCKGFFRRT | IQKNLHPTYS | CKYDSCCVID | 
    150:
    KITRNQCQLC | RFKKCIAVGM | AMDLVLDDSK | RVAKRKLIEQ | NRERRRKEEM | 
    200:
    IRSLQQRPEP | TPEEWDLIHV | ATEAHRSTNA | QGSHWKQRRK | FLPDDIGQSP | 
    250:
    IVSMPDGDKV | DLEAFSEFTK | IITPAITRVV | DFAKKLPMFS | ELPCEDQIIL | 
    300:
    LKGCCMEIMS | LRAAVRYDPE | SDTLTLSGEM | AVKREQLKNG | GLGVVSDAIF | 
    350:
    ELGKSLSAFN | LDDTEVALLQ | AVLLMSTDRS | GLLCVDKIEK | SQEAYLLAFE | 
    400:
    HYVNHRKHNI | PHFWPKLLMK | EREVQSSILY | KGAAAEGRPG | GSLGVHPEGQ | 
    450:
    QLLGMHVVQG | PQVRQLEQQF | GEAGSLRGPV | LQHQSPKSPQ | QRLLELLHRS | 
    492:
    GILHSRAVCG | EDDSSEASSL | SSSSSDEDTE | VFEDLAGKAA | SP
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    SMR:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Thyroid hormone receptor alpha
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    E1927r
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    96T
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    ELISA Kit for Rat Thyroid hormone receptor alpha
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    E1927h
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    ELISA Kit for Rat Thyroid hormone receptor alpha
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    E1927p
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    ELISA Kit for Rat Thyroid hormone receptor alpha
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    E1927c
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    ELISA Kit for Rat Thyroid hormone receptor alpha
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    E1927m
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    96T
    CLIA Kit for Rat Thyroid hormone receptor alpha
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    U1927h
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    Packing:
    96T
    CLIA Kit for Rat Thyroid hormone receptor alpha
    Cat.:
    U1927c
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    96T
    CLIA Kit for Rat Thyroid hormone receptor alpha
    Cat.:
    U1927r
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    Packing:
    96T
    CLIA Kit for Rat Thyroid hormone receptor alpha
    Cat.:
    U1927m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Thyroid hormone receptor alpha
    Cat.:
    U1927p
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    Packing:
    96T
    Polyclonal Antibody for Rat Thyroid hormone receptor alpha
    Cat.:
    P1927Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Thyroid hormone receptor alpha
    Polyclonal Antibody for Rat Thyroid hormone receptor alpha
    Cat.:
    P1927Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Thyroid hormone receptor alpha
    Cat.:
    P1927Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Thyroid hormone receptor alpha
    Monoclonal Antibody for Rat Thyroid hormone receptor alpha
    Monoclonal Antibody for Rat Thyroid hormone receptor alpha
    Monoclonal Antibody for Rat Thyroid hormone receptor alpha
    Monoclonal Antibody for Rat Thyroid hormone receptor alpha
    Monoclonal Antibody for Rat Thyroid hormone receptor alpha
    Protein for Rat Thyroid hormone receptor alpha
    Protein for Rat Thyroid hormone receptor alpha
    Protein for Rat Thyroid hormone receptor alpha
    Protein for Rat Thyroid hormone receptor alpha
    Protein for Rat Thyroid hormone receptor alpha

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    References
    1. 1.
      "Thyroid hormone receptor alpha isoforms generated by alternative splicing differentially activate myosin HC gene transcription."
      Izumo S. , Mahdavi V.
      Nature334:539-542(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA-1 AND ALPHA-2)
    2. 2.
      "Nucleotide sequence of novel cDNAs generated by alternative splicing of a rat thyroid hormone receptor gene transcript."
      Mitsuhashi T. , Tennyson G. , Nikodem V.
      Nucleic Acids Res.16:5697-5697(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-2)
    3. 3.
      "Identification of a rat c-erbA alpha-related protein which binds deoxyribonucleic acid but does not bind thyroid hormone."
      Lazar M.A. , Hodin R.A. , Darling D.S. , Chin W.W.
      Mol. Endocrinol.2:893-901(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-2)
    4. 4.
      "Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system."
      Thompson C.C. , Weinberger C. , Lebo R. , Evans R.M.
      Science237:1610-1614(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-1)
    5. 5.
      Flink I.L. , Bailey T. , Bahl J. , Morkin E.
      Submitted (1988-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-492 (ISOFORM ALPHA-1)
      tissue: Heart.
    6. 6.
      "A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP."
      Mahajan M.A. , Samuels H.H.
      Mol. Cell. Biol.20:5048-5063(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA6
    7. 7.
      "A structural role for hormone in the thyroid hormone receptor."
      Wagner R.L. , Apriletti J.W. , McGrath M.E. , West B.L. , Baxter J.D. , Fletterick R.J.
      Nature378:690-697(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 152-410 (ISOFORM ALPHA-1)
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